If the inclusion of the Leipzig's striker in the first eleven, given the absence of the suspended Cristiano Ronaldo, was already predictable, then the inclusion of the Wolverhampton midfielder has caused some surprise.
The Portuguese team will start with Rui Patrício in goal, behind a defensive quartet formed by João Cancelo, Rúben Dias, Pepe and Raphaël Guerreiro, while João Palhinha, 'captain' João Moutinho and Bruno Fernandes will compose the midfield.
Bernardo Silva, Diogo Jota and André Silva are the options for the attacking front.
Azerbaijan and Portugal will face each other at the Olympic Stadium in Baku, located near the centre of the capital, from 17:00 (Lisbon time).
Portugal is one of the leaders in group A, with 10 points, alongside Serbia who today faces the Republic of Ireland in Dublin.