The screening will be the world premiere of the film, which takes place 36 years after the events of the original movie, reuniting stars Michael Keaton and Winona Ryder with Burton, and features Wednesday’s Jenna Ortega as Astrid Deetz, the daughter of Ryder's character Lydia Deetz.
Keaton returns as "bio-exorcist" Beetlejuice, with Monica Bellucci appearing as ex-wife Delores. Written by Alfred Gough and Miles Millar, the sequel has been long in the works, with versions in development as far back as the late 1980s.
The Venice Film Festival starts on 28 August and runs until 7 September.